Loh Lab

UK Biobank clonal hematopoiesis paper published in Nature

Our work on mosaic chromosomal alterations in the UK Biobank N=150K interim release has been published in Nature! This study used long-range haplotype phasing information to detect mosaicism in blood at very low clonal fractions (down to ~1%), producing an atlas of 8,342 mosaic events. The statistical power of this data set revealed several rare inherited variants that strongly influence clonal expansions involving nearby chromosomal alterations and also refined the link between mosaicism and future blood cancers. [Article] [Free full-text link] [HMS press release] [BWH press release]