Loh Lab

Papers

2022

Hujoel MLA, Sherman MA, Barton AR, Mukamel RE, Sankaran VG, Terao C, Loh P-R. Influences of rare copy-number variation on human complex traits. Cell 2022;185(22):4233-4248.e27.

Abstract

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, .., Loh P-R, Yang J, Esko T, Assimes TL, Auton A, Abecasis GR, Willer CJ, Locke AE, Berndt SI, Lettre G, Frayling TM, Okada Y, Wood AR, Visscher PM, Hirschhorn JN. A saturated map of common genetic variants associated with human height. Nature 2022;

Abstract

Gao T, Soldatov R, Sarkar H, Kurkiewicz A, Biederstedt E, Loh P-R, Kharchenko PV. Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes. Nat Biotechnol 2022;

Abstract

Genovese G, Mello CJ, Loh P-R, Handsaker RE, Kashin S, Whelan CW, Bayer-Zwirello LA, McCarroll SA. Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions. Sci Rep 2022;12(1):12025.

Abstract

Hujoel MLA, Loh P-R, Neale BM, Price AL. Incorporating family history of disease improves polygenic risk scores in diverse populations. Cell Genom 2022;2(7):100152.

Abstract

Sherman MA, Yaari AU, Priebe O, Dietlein F, Loh P-R, Berger B. Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. Nat Biotechnol 2022;

Abstract

Barton AR, Hujoel MLA, Mukamel RE, Sherman MA, Loh P-R. A spectrum of recessiveness among Mendelian disease variants in UK Biobank. Am J Hum Genet 2022;109(7):1298-1307.

Abstract

2021

Márquez-Luna C, Gazal S, Loh P-R, Kim SS, Furlotte N, Auton A, Auton A, Price AL. Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets. Nat Commun 2021;12(1):6052.

Abstract

Mukamel RE, Handsaker RE, Sherman MA, Barton AR, Zheng Y, McCarroll SA, Loh P-R. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes. Science 2021;373(6562):1499-1505.

Abstract

Zhao Y, Stankovic S, Koprulu M, Wheeler E, Day FR, Lango Allen H, Kerrison ND, Pietzner M, Loh P-R, Wareham NJ, Langenberg C, Ong KK, Perry JRB. GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health. Nat Commun 2021;12(1):4178.

Abstract

Barton AR, Sherman MA, Mukamel RE, Loh P-R. Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses. Nat Genet 2021;53(8):1260-1269.

Abstract

Zekavat SM, Lin S-H, Bick AG, Liu A, Paruchuri K, Wang C, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Bhattacharya R, Pirruccello JP, Pampana A, Loh P-R, Kohli P, McCarroll SA, Kiryluk K, Neale B, Ionita-Laza I, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, Daly MJ, Daly MJ, Terao C, Zhao H, Ebert BL, Reilly MP, Ganna A, Machiela MJ, Genovese G, Natarajan P. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med 2021;27(6):1012-1024.

Abstract

Sheppard B, Rappoport N, Loh P-R, Sanders SJ, Zaitlen N, Dahl A. A model and test for coordinated polygenic epistasis in complex traits. Proc Natl Acad Sci U S A 2021;118(15):e1922305118.

Abstract

Ziyatdinov A, Kim J, Prokopenko D, Privé F, Laporte F, Loh P-R, Kraft P, Aschard H. Estimating the effective sample size in association studies of quantitative traits. G3 2021;11(6):jkab057.

Abstract

Sherman MA, Rodin RE, Genovese G, Dias C, Barton AR, Mukamel RE, Berger B, Park PJ, Walsh CA, Loh P-R. Large mosaic copy number variations confer autism risk. Nat Neurosci 2021;24(2):197-203.

Abstract

2020

Brown DW, Lin S-H, Loh P-R, Chanock SJ, Savage SA, Machiela MJ. Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes. PLoS Genet 2020;16(10):e1009078.

Abstract

Loh P-R, Genovese G, McCarroll SA. Monogenic and polygenic inheritance become instruments for clonal selection. Nature 2020;584(7819):136-141.

Abstract

Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh P-R, Kamatani Y. Chromosomal alterations among age-related haematopoietic clones in Japan. Nature 2020;584(7819):130-135.

Abstract

Hujoel MLA, Gazal S, Loh P-R, Patterson N, Price AL. Liability threshold modeling of case-control status and family history of disease increases association power. Nat Genet 2020;52(5):541-547.

Abstract

2019

Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y, Danielsson M, Davies H, Dennis J, Dunlop MG, Easton DF, Fisher VA, Zink F, Houlston RS, Ingelsson M, Kar S, Kerrison ND, Kinnersley B, Kristjansson RP, Law PJ, Li R, Loveday C, Mattisson J, McCarroll SA, Murakami Y, Murray A, Olszewski P, Rychlicka-Buniowska E, Scott RA, Thorsteinsdottir U, Tomlinson I, Moghadam BT, Turnbull C, Wareham NJ, Gudbjartsson DF, Kamatani Y, Hoffmann ER, Jackson SP, Stefansson K, Auton A, Ong KK, Machiela MJ, Loh P-R, Dumanski JP, Chanock SJ, Forsberg LA, Perry JRB. Genetic predisposition to mosaic Y chromosome loss in blood. Nature 2019;575(7784):652-657.

Abstract

Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh P-R, Raychaudhuri S. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods 2019;16(12):1289-1296.

Abstract

Terao C, Momozawa Y, Ishigaki K, Kawakami E, Akiyama M, Loh P-R, Genovese G, Sugishita H, Ohta T, Hirata M, Perry JRB, Matsuda K, Murakami Y, Kubo M, Kamatani Y. GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation. Nat Commun 2019;10(1):4719.

Abstract

van de Geijn B, Finucane H, Gazal S, Hormozdiari F, Amariuta T, Liu X, Gusev A, Loh P-R, Reshef Y, Kichaev G, Raychauduri S, Price AL. Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability. Hum Mol Genet 2019;

Abstract

Kim SS, Dai C, Hormozdiari F, van de Geijn B, Gazal S, Park Y, O’Connor L, Amariuta T, Loh P-R, Finucane H, Raychaudhuri S, Price AL. Genes with High Network Connectivity Are Enriched for Disease Heritability. Am J Hum Genet 2019;104(5):896-913.

Abstract

Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, Wood AR, Mahajan A, Tyrrell J, Robertson NR, Rayner WN, Qiao Z, Moen G-H, Vaudel M, Marsit CJ, Chen J, Nodzenski M, Schnurr TM, Zafarmand MH, Bradfield JP, Grarup N, Kooijman MN, Li-Gao R, Geller F, Ahluwalia TS, Paternoster L, Rueedi R, Huikari V, Hottenga J-J, Lyytikäinen L-P, Cavadino A, Metrustry S, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Vilor-Tejedor N, Joshi PK, Painter JN, Ntalla I, Myhre R, Pitkänen N, van Leeuwen EM, Joro R, Lagou V, Richmond RC, Espinosa A, Barton SJ, Inskip HM, Holloway JW, Santa-Marina L, Estivill X, Ang W, Marsh JA, Reichetzeder C, Marullo L, Hocher B, Lunetta KL, Murabito JM, Relton CL, Kogevinas M, Chatzi L, Allard C, Bouchard L, Hivert M-F, Zhang G, Muglia LJ, Heikkinen J, Morgen CS, van Kampen AHC, van Schaik BDC, Mentch FD, Langenberg C, Luan J’an, Scott RA, Zhao JH, Hemani G, Ring SM, Bennett AJ, Gaulton KJ, Fernandez-Tajes J, van Zuydam NR, Medina-Gomez C, de Haan HG, Rosendaal FR, Kutalik Z, Marques-Vidal P, Das S, Willemsen G, Mbarek H, Müller-Nurasyid M, Standl M, Appel EVR, Fonvig CE, Trier C, van Beijsterveldt CE, Murcia M, Bustamante M, Bonas-Guarch S, Hougaard DM, Mercader JM, Linneberg A, Schraut KE, Lind PA, Medland SE, Shields BM, Knight BA, Chai J-F, Panoutsopoulou K, Bartels M, Sánchez F, Stokholm J, Torrents D, Vinding RK, Willems SM, Atalay M, Chawes BL, Kovacs P, Prokopenko I, Tuke MA, Yaghootkar H, Ruth KS, Jones SE, Loh P-R, .., Ong KK, McCarthy MI, Perry JRB, Evans DM, Freathy RM. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet 2019;51(5):804-814.

Abstract

Galinsky KJ, A Reshef Y, Finucane HK, Loh P-R, Zaitlen N, Patterson NJ, Brown BC, Price AL. Estimating cross-population genetic correlations of causal effect sizes. Genet Epidemiol 2019;43(2):180-188.

Abstract

Schoech AP, Jordan DM, Loh P-R, Gazal S, O’Connor LJ, Balick DJ, Palamara PF, Finucane HK, Sunyaev SR, Price AL. Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection. Nat Commun 2019;10(1):790.

Abstract

Chung W, Chen J, Turman C, Lindstrom S, Zhu Z, Loh P-R, Kraft P, Liang L. Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes. Nat Commun 2019;10(1):569.

Abstract

Kichaev G, Bhatia G, Loh P-R, Gazal S, Burch K, Freund MK, Schoech A, Pasaniuc B, Price AL. Leveraging Polygenic Functional Enrichment to Improve GWAS Power. Am J Hum Genet 2019;104(1):65-75.

Abstract

2018

Gazal S, Loh P-R, Finucane HK, Ganna A, Schoech A, Sunyaev S, Price AL. Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations. Nat Genet 2018;50(11):1600-1607.

Abstract

Reshef YA, Finucane HK, Kelley DR, Gusev A, Kotliar D, Ulirsch JC, Hormozdiari F, Nasser J, O’Connor L, van de Geijn B, Loh P-R, Grossman SR, Bhatia G, Gazal S, Palamara PF, Pinello L, Patterson N, Adams RP, Price AL. Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nat Genet 2018;50(10):1483-1493.

Abstract

Loh P-R, Genovese G, Handsaker RE, Finucane HK, A Reshef Y, Palamara PF, Birmann BM, Talkowski ME, Bakhoum SF, McCarroll SA, Price AL. Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations. Nature 2018;559(7714):350-355.

Abstract

Hormozdiari F, Gazal S, van de Geijn B, Finucane HK, Ju CJ-T, Loh P-R, Schoech A, Reshef Y, Liu X, O’Connor L, Gusev A, Eskin E, Price AL. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat Genet 2018;50(7):1041-1047.

Abstract

Loh P-R, Kichaev G, Gazal S, Schoech AP, Price AL. Mixed-model association for biobank-scale datasets. Nat Genet 2018;50(7):906-908.

Zhu Z, Lee PH, Chaffin MD, Chung W, Loh P-R, Lu Q, Christiani DC, Liang L. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet 2018;50(6):857-864.

Abstract

Finucane HK, A Reshef Y, Anttila V, Slowikowski K, Gusev A, Byrnes A, Gazal S, Loh P-R, Lareau C, Shoresh N, Genovese G, Saunders A, Macosko E, Pollack S, Pollack S, Perry JRB, Buenrostro JD, Bernstein BE, Raychaudhuri S, McCarroll S, Neale BM, Price AL. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat Genet 2018;50(4):621-629.

Abstract

2017

Weng L-C, Choi SH, Klarin D, Smith GJ, Loh P-R, Chaffin M, Roselli C, Hulme OL, Lunetta KL, Dupuis J, Benjamin EJ, Newton-Cheh C, Kathiresan S, Ellinor PT, Lubitz SA. Heritability of Atrial Fibrillation. Circ Cardiovasc Genet 2017;10(6)

Abstract

Márquez-Luna C, Loh P-R, Price AL. Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol 2017;41(8):811-823.

Abstract

Gazal S, Finucane HK, Furlotte NA, Loh P-R, Palamara PF, Liu X, Schoech A, Bulik-Sullivan B, Neale BM, Gusev A, Price AL. Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection. Nat Genet 2017;49(10):1421-1427.

Abstract

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton KJ, Lotta LA, Miyamoto-Mikami E, Rivas MA, White T, Loh P-R, .., Rivadeneira F, Langenberg C, Perry JRB, Wareham NJ, Scott RA. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nat Commun 2017;8:16015.

Abstract

Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, Demerath E, Giri A, He C, Hottenga JJ, Karlsson R, Kolcic I, Loh P-R, .., Murray A, Murabito JM, Stefansson K, Ong KK, Perry JRB. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet 2017;49(6):834-841.

Abstract

Hill A, Loh P-R, Bharadwaj RB, Pons P, Shang J, Guinan E, Lakhani K, Kilty I, Jelinsky SA. Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis. Gigascience 2017;6(5):1-10.

Abstract

Hayeck TJ, Loh P-R, Pollack S, Gusev A, Patterson N, Zaitlen NA, Price AL. Mixed Model Association with Family-Biased Case-Control Ascertainment. Am J Hum Genet 2017;100(1):31-39.

Abstract

2016

Galinsky KJ, Loh P-R, Mallick S, Patterson NJ, Price AL. Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure. Am J Hum Genet 2016;99(5):1130-1139.

Abstract

Loh P-R, Danecek P, Palamara PF, Fuchsberger C, A Reshef Y, Finucane HK, Schoenherr S, Forer L, McCarthy S, Abecasis GR, Durbin R, Price AL. Reference-based phasing using the Haplotype Reference Consortium panel. Nat Genet 2016;48(11):1443-1448.

Abstract

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen L-P, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga J-J, Vilor-Tejedor N, Joshi PK, Boh ETH, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH, Tam WH, Ganesh SK, van Rooij FJA, Jones SE, Loh P-R, .., Timpson NJ, Perry JRB, Evans DM, McCarthy MI, Freathy RM. Genome-wide associations for birth weight and correlations with adult disease. Nature 2016;538(7624):248-252.

Abstract

Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh P-R, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C. Next-generation genotype imputation service and methods. Nat Genet 2016;48(10):1284-1287.

Abstract

Loh P-R, Palamara PF, Price AL. Fast and accurate long-range phasing in a UK Biobank cohort. Nat Genet 2016;48(7):811-6.

Abstract

Day FR, Helgason H, Chasman DI, Rose LM, Loh P-R, Scott RA, Helgason A, Kong A, Masson G, Magnusson OT, Gudbjartsson D, Thorsteinsdottir U, Buring JE, Ridker PM, Sulem P, Stefansson K, Ong KK, Perry JRB. Physical and neurobehavioral determinants of reproductive onset and success. Nat Genet 2016;48(6):617-623.

Abstract

Galinsky KJ, Bhatia G, Loh P-R, Georgiev S, Mukherjee S, Patterson NJ, Price AL. Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. Am J Hum Genet 2016;98(3):456-72.

Abstract

Day FR, Loh P-R, Scott RA, Ong KK, Perry JRB. A Robust Example of Collider Bias in a Genetic Association Study. Am J Hum Genet 2016;98(2):392-3.

2015

Loh P-R, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ, de Candia TR, Lee SH, Wray NR, Kendler KS, O’Donovan MC, Neale BM, Patterson N, Price AL. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet 2015;47(12):1385-92.

Abstract

Lipson M, Loh P-R, Sankararaman S, Patterson N, Berger B, Reich D. Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes. PLoS Genet 2015;11(11):e1005550.

Abstract

Tucker G*, Loh P-R*, MacLeod IM, Hayes BJ, Goddard ME, Berger B, Price AL. Two-Variance-Component Model Improves Genetic Prediction in Family Datasets. Am J Hum Genet 2015;97(5):677-90.

Abstract

Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh P-R, Duncan L, Perry JRB, Patterson N, Robinson EB, Daly MJ, Price AL. An atlas of genetic correlations across human diseases and traits. Nat Genet 2015;47(11):1236-41.

Abstract

Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, Loh P-R, Anttila V, Xu H, Zang C, Farh K, Ripke S, Day FR, Day FR, Purcell S, Stahl E, Lindstrom S, Perry JRB, Okada Y, Raychaudhuri S, Daly MJ, Patterson N, Neale BM. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet 2015;47(11):1228-35.

Abstract

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh P-R, Bhatia G, Do R, Hayeck T, Won H-H, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet 2015;97(4):576-92.

Abstract

Hayeck TJ, Zaitlen NA, Loh P-R, Vilhjalmsson B, Pollack S, Gusev A, Yang J, Chen G-B, Goddard ME, Visscher PM, Patterson N, Price AL. Mixed model with correction for case-control ascertainment increases association power. Am J Hum Genet 2015;96(5):720-30.

Abstract

Loh P-R, Tucker G, Bulik-Sullivan BK, Vilhjálmsson BJ, Finucane HK, Salem RM, Chasman DI, Ridker PM, Neale BM, Berger B, Patterson N, Price AL. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet 2015;47(3):284-90.

Abstract

Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Daly MJ, Price AL, Neale BM. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 2015;47(3):291-5.

Abstract

2014

Price AL, Loh P-R. Genomic prediction and genome wide association in humans with whole genome sequence data. Proceedings of the 10th World Congress of Genetics Applied to Livestock Production (WCGALP) 2014;

Lipson M, Loh P-R, Patterson N, Moorjani P, Ko Y-C, Stoneking M, Berger B, Reich D. Reconstructing Austronesian population history in Island Southeast Asia. Nat Commun 2014;5:4689.

Abstract

Pickrell JK, Patterson N, Loh P-R, Lipson M, Berger B, Stoneking M, Pakendorf B, Reich D. Ancient west Eurasian ancestry in southern and eastern Africa. Proc Natl Acad Sci U S A 2014;111(7):2632-7.

Abstract

Meyer P, Cokelaer T, Chandran D, Kim KH, Loh P-R, Tucker G, Lipson M, Berger B, Kreutz C, Raue A, Steiert B, Timmer J, Bilal E, Sauro HM, Stolovitzky G, Saez-Rodriguez J. Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach. BMC Syst Biol 2014;8:13.

Abstract

2013

Tucker G*, Loh P-R*, Berger B. A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis. BMC Bioinformatics 2013;14:299.

Abstract

Moorjani P, Thangaraj K, Patterson N, Lipson M, Loh P-R, Govindaraj P, Berger B, Reich D, Singh L. Genetic evidence for recent population mixture in India. Am J Hum Genet 2013;93(3):422-38.

Abstract

Lipson M*, Loh P-R*, Levin A, Reich D, Patterson N, Berger B. Efficient moment-based inference of admixture parameters and sources of gene flow. Mol Biol Evol 2013;30(8):1788-802.

Abstract

Loh P-R*, Lipson M*, Patterson N, Moorjani P, Pickrell JK, Reich D, Berger B. Inferring admixture histories of human populations using linkage disequilibrium. Genetics 2013;193(4):1233-54.

Abstract

Moorjani P, Patterson N, Loh P-R, Lipson M, Kisfali P, Melegh BI, Bonin M, Kádaši L, Rieß O, Berger B, Reich D, Melegh B. Reconstructing Roma history from genome-wide data. PLoS One 2013;8(3):e58633.

Abstract

Lakhani KR, Boudreau KJ, Loh P-R, Backstrom L, Baldwin C, Lonstein E, Lydon M, MacCormack A, Arnaout RA, Guinan EC. Prize-based contests can provide solutions to computational biology problems. Nat Biotechnol 2013;31(2):108-11.

2012

Pickrell JK, Patterson N, Barbieri C, Berthold F, Gerlach L, Güldemann T, Kure B, Mpoloka SW, Nakagawa H, Naumann C, Lipson M, Loh P-R, Lachance J, Mountain J, Bustamante CD, Berger B, Tishkoff SA, Henn BM, Stoneking M, Reich D, Pakendorf B. The genetic prehistory of southern Africa. Nat Commun 2012;3:1143.

Abstract

Loh P-R*, Baym M*, Berger B. Compressive genomics. Nat Biotechnol 2012;30(7):627-30.

Chindelevitch L, Loh P-R, Enayetallah A, Berger B, Ziemek D. Assessing statistical significance in causal graphs. BMC Bioinformatics 2012;13:35.

Abstract

Garcia-Reyero N, Escalon LB, Loh P-R, Laird JG, Kennedy AJ, Berger B, Perkins EJ. Assessment of chemical mixtures and groundwater effects on Daphnia magna transcriptomics. Environ Sci Technol 2012;46(1):42-50.

Abstract

Gong P, Loh P-R, Barker ND, Tucker G, Wang N, Zhang C, Escalon LB, Berger B, Perkins EJ. Building quantitative prediction models for tissue residue of two explosives compounds in earthworms from microarray gene expression data. Environ Sci Technol 2012;46(1):19-26.

Abstract

2011

Demaine E, Demaine M, Hawksley A, Ito H, Loh P-R, Manber S, Stephens O. Making polygons by simple folds and one straight cut. Computational Geometry, Graphs and Applications 2011;:27–43.

Loh P-R, Tucker G, Berger B. Phenotype prediction using regularized regression on genetic data in the DREAM5 Systems Genetics B Challenge. PLoS One 2011;6(12):e29095.

Abstract

2009

Loh P-R, Oskooi AF, Ibanescu M, Skorobogatiy M, Johnson SG. Fundamental relation between phase and group velocity, and application to the failure of perfectly matched layers in backward-wave structures. Phys Rev E Stat Nonlin Soft Matter Phys 2009;79(6 Pt 2):065601.

Abstract

2007

Loh P-R. Stepping to infinity along Gaussian primes. American Mathematical Monthly 2007;114(2):142–151.

2006

Loh P-R, Rhoades RC. p-adic and combinatorial properties of modular form coefficients. International Journal of Number Theory 2006;2(02):305–328.