Loh Lab

Paper on cancer mutation modeling published in Nature Biotechnology

Maxwell Sherman’s paper on modeling somatic mutation rates to uncover cancer drivers (Sherman*, Yaari*, Priebe* et al. 2022 Nat Biotech) is now published — congratulations, Max! This work, a collaboration with Bonnie Berger’s group at MIT, developed a deep-learning model to predict cancer-specific neutral mutation rates at kilobase-scale resolution from epigenomic annotations. Applying this model to the Pan-Cancer Analysis of Whole Genomes (PCAWG) resource identified potential new driver mutations in understudied regions of the genome, including cryptic alternative splice sites, 5′ UTRs, and infrequently-mutated driver genes. [ MIT news story ]